This dissertation describes an ergonomic study of engineers at an aerospace firm. The first paper is a cross-sectional study intended to investigate the risk factors associated with entrapment neuropathies at the wrist. The second and third papers describe a randomized controlled trial designed to determine whether a forearm support board and/or a neutral forearm posture mouse, when used by engineers with heavy computer usage, would (1) reduce the incidence of upper body musculoskeletal disorders, (2) reduce discomfort severity, and (3) alter the distal motor latency of the median or ulnar nerve at the right wrist.