Fenofibrate is a fibric acid derivative that activates peroxisome proliferator activated receptor type (PPAR) alpha, thereby reducing production of apoprotein CIII and increases the synthesis of apoproteins AI and AII. Simvastatin is hydrolyzed to its active beta-hydroxyacid metabolite, which inhibits HMG-CoA reductase, the rate-limiting step of cholesterol biosynthesis [1].