he literature review was made using Scifinder (CAS), using the structure of 1 as starting material in the "Search reaction" option. Also, in Scifinder we applied the following filter for results retrieving: aphidicolin + semisynthesis or aphidicolin + medicinal chemistry. The physicochemical properties for the aphidicolin and set of derivatives were calculated using the program Vortex (Dotmatics, UK).