The donor compartment was kept in contact with the receptor compartment and the temperature was maintained at 37±0.50C. The solutions on the receptor side were stirred by externally driven Teflon-coated magnetic bars. At pre-determined time intervals, 5 ml of solution from the receptor compartment was pipetted out and immediately replaced with 5 ml fresh phosphate buffer solution. The drug concentration of the receptor fluidwas determined spectrophotometrically at 271nm against appropriate blank