If the VN architecture is now the mainstream architecture for modern computers, it might not be very adapted to the unique properties of nano-fabricated components. Indeed, the VN structure requires a precise assembly of very reliable components when nano-components are likely to have relatively high defect rates and questionable reliability. Additionally the internal structure of a VN computer is rather complex with a clear separation between memory banks and computing circuits that requires a complex and non-local wiring scheme. For all of those reasons and many more that we will develop during the talk, the VN architecture is not the wining choice for current research in nanocomputing.