In summary, supplementation with vitamin C (at a dose of 1000 mg daily) and vitamin E (at a dose of 400 IU daily) did not reduce the rates ofeither serious adverse outcomes of pregnancy-associated hypertension or preeclampsia among
low-risk, nulliparous women. Previous studies have shown a similar lack of eff icacy among high-risk women and among women who were likely to have had a deficiency of vitamins C and E. The findings of these several studies provide no support for the use of vitamin C and E supplementation in preg-nancy to reduce the risk of preeclampsia or its complications