PPHN is often associated with the following signs and symptoms of perinatal distress:
Asphyxia
Tachypnea, respiratory distress
Loud, single second heart sound (S2) or a harsh systolic murmur (secondary to tricuspid regurgitation)
Low Apgar scores
Meconium staining
Cyanosis; poor cardiac function and perfusion
Systemic hypotension
Symptoms of shock