Consequently, in this study, we combined the use of seagrass bioindicators, environmental variables, and spatial analysis to (1) confirm whether a nutrient gradient exists in the Xincun seagrass meadow, (2) elucidate the physiological responses of the seagrass T. hemprichii to nutrient loading, and (3) report the capacity of each descriptor that responds to the nutrient regime and evaluate their usefulness as early indicators of marine environmental degradation caused by aquacultural activities and sewage effluent.