Overall, this study (5) sheds light on
how metabolic pathways, such as glycolysis
and glutaminolysis, are linked to cell cycle
progression. Given their timely and selective
targeting of substrates, APC/CCdh1
and SCFβTrCP coordinate global metabolism
networks with the cell cycle. Further
investigation will provide important information
about the contribution of metabolic
pathways to cell growth and
malignancy, as well as the specific metabolic
features coopted by tumor cells