The formationoftheanteroposteriorax

The formationoftheanteroposterioraxisinmicerequiresa Wnt3-dependentsymmetry-breakingevent
that leadstotheformationoftheprimitivestreakandgastrulation. Wnt3 is expressedsequentiallyin
two distinctareasofthemouseembryobeforetheappearanceoftheprimitivestreak;firstinthe
posteriorvisceralendodermandsoonafterintheadjacentposteriorepiblast.Hence,althoughanaxial
requirementfor Wnt3 is wellestablished,itstemporalandtissuespecificrequirementsremainanopen
question.Here,wereporttheconditionalinactivationof Wnt3 in theepiblastofdevelopingmouse
embryos.Contrarytopreviousstudies,ourdatashowsthatembryoslacking Wnt3 specificallyinthe
epiblastareabletoinitiategastrulationandadvancetolateprimitivestreakstagesbutfailtothrive
and areresorbedbyE9.5.Atthemolecularlevel,weprovideevidencethat Wnt3 regulatesitsown
expressionandthatofotherprimitivestreakmarkersviaactivationofthecanonicalWntsignaling
pathway.

ผลลัพธ์ (ไทย) 1:

Formationoftheanteroposterioraxisinmicerequiresa Wnt3 dependentsymmetry breakingevent
leadstotheformationoftheprimitivestreakandgastrulation ที่ Wnt3 เป็น expressedsequentiallyin
2 distinctareasofthemouseembryobeforetheappearanceoftheprimitivestreak; firstinthe
posteriorvisceralendodermandsoonafterintheadjacentposteriorepiblastดังนั้น althoughanaxial
requirementfor Wnt3 เป็น wellestablisheditstemporalandtissuespecificrequirementsremainanopen
คำถามที่นี่ wereporttheconditionalinactivationof Wnt3 theepiblastofdevelopingmouse
โคลนContrarytopreviousstudies, specificallyinthe ourdatashowsthatembryoslacking Wnt3
epiblastareabletoinitiategastrulationandadvancetolateprimitivestreakstagesbutfailtothrive
areresorbedbyE9.5.Atthemolecularlevel และregulatesitsown weprovideevidencethat Wnt3
expressionandthatofotherprimitivestreakmarkersviaactivationofthecanonicalWntsignaling
ทางเดิน

ผลลัพธ์ (ไทย) 2:

formationoftheanteroposterioraxisinmicerequiresa Wnt3-dependentsymmetry-breakingevent
ที่ leadstotheformationoftheprimitivestreakandgastrulation Wnt3 เป็น expressedsequentiallyin
สอง Wnt3 เป็น Wnt3 ใน theepiblastofdevelopingmouse embryos.Contrarytopreviousstudies, ourdatashowsthatembryoslacking Wnt3 areresorbedbyE9.5.Atthemolecularlevel, weprovideevidencethat Wnt3

ผลลัพธ์ (ไทย) 3:

การ formationoftheanteroposterioraxisinmicerequiresa wnt3 dependentsymmetry breakingevent
ที่ leadstotheformationoftheprimitivestreakandgastrulation . wnt3 เป็น expressedsequentiallyin
2 distinctareasofthemouseembryobeforetheappearanceoftheprimitivestreak ; firstinthe
posteriorvisceralendodermandsoonafterintheadjacentposteriorepiblast ดังนั้น althoughanaxial
requirementfor เป็น wellestablished wnt3 ,itstemporalandtissuespecificrequirementsremainanopen
คำถามที่นี่ wereporttheconditionalinactivationof wnt3 ใน theepiblastofdevelopingmouse
ตัวอ่อน . contrarytopreviousstudies ourdatashowsthatembryoslacking wnt3 , specificallyinthe

areresorbedbye9.5.atthemolecularlevel epiblastareabletoinitiategastrulationandadvancetolateprimitivestreakstagesbutfailtothrive และ ,weprovideevidencethat wnt3 expressionandthatofotherprimitivestreakmarkersviaactivationofthecanonicalwntsignaling regulatesitsown

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