We projected that achieving the blood-pressure treatment goal of 150/90 mm Hg for patients between the ages of 60 and 74 years, as recommended in the 2014 guidelines, would be cost-effective, even when we assumed a higher rate of medication side effects in this group. However, patients between the ages of 60 and 74 years have variable levels of functional status and susceptibility to side effects of medications and adverse events. Better predictors of adverse effects of medications are needed to guide the decision to withhold or withdraw treatment from individual patients in this age group. Controversy persists about the systolic blood-pressure treatment target of 150 mm Hg in the 2014 guidelines,18 and future research must address the question of whether a lower target is indicated and, if so, in which patients.