Inthis study,anantibacterialelectrospunnanofibrous scaffoldswithdiametersaround400–700nmwere
prepared by physically blending polyurethane (PU) with two biopolymers such as cellulose acetate (CA)
and zein. Here, PU was used as the foundation polymer, was blended with CA and zein to achieve desirable properties such as better hydrophilicity, excellent cell attachment, proliferation and blood clotting
ability.Toprevent commonclinicalinfections, anantimicrobial agent, streptomycinsulfatewas incorporatedintotheelectrospunfibersanditsantimicrobialabilityagainstthegramnegativeandgrampositive
bacteria were examined. The interactionbetweenfibroblasts andthe PU–CAandPU–CA–zein-drug scaffolds such as viability, proliferation, and attachment were characterized. PU–CA–zein-drug composite
nanoscaffold showed enhanced blood clotting ability in comparison with pristine PU nanofibers. The
presence of CAand zein in the nanofiber membrane improved its hydrophilicity, bioactivity and created
a moist environmentfor the wound, which can accelerate wound recovery.
Inthis study,anantibacterialelectrospunnanofibrous scaffoldswithdiametersaround400–700nmwere
prepared by physically blending polyurethane (PU) with two biopolymers such as cellulose acetate (CA)
and zein. Here, PU was used as the foundation polymer, was blended with CA and zein to achieve desirable properties such as better hydrophilicity, excellent cell attachment, proliferation and blood clotting
ability.Toprevent commonclinicalinfections, anantimicrobial agent, streptomycinsulfatewas incorporatedintotheelectrospunfibersanditsantimicrobialabilityagainstthegramnegativeandgrampositive
bacteria were examined. The interactionbetweenfibroblasts andthe PU–CAandPU–CA–zein-drug scaffolds such as viability, proliferation, and attachment were characterized. PU–CA–zein-drug composite
nanoscaffold showed enhanced blood clotting ability in comparison with pristine PU nanofibers. The
presence of CAand zein in the nanofiber membrane improved its hydrophilicity, bioactivity and created
a moist environmentfor the wound, which can accelerate wound recovery.
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