Nineteen studies relating to 10 outcomes were included in the review. The inclusion criteria for the outcomes had been prespecified and based on the Global Burden of Disease Study. The authors concluded that no single optimal pattern of infant growth was associated with beneficial adult health outcomes. Larger infant
size was associated with a reduced risk of ischemic heart disease, but also with an
increased risk of type 1 diabetes. Very few or no studies associating infant size or
growth with diseases such as cancer, mental illness, chronic obstructive disease, and
type 2 diabetes were found. The authors identified a number of methodological
limitations in the included trials. Furthermore, the authors stated that most of the
evidence related to infant size, not to infant growth or actual size that is associated
with the disease risk.
Nineteen studies relating to 10 outcomes were included in the review. The inclusion criteria for the outcomes had been prespecified and based on the Global Burden of Disease Study. The authors concluded that no single optimal pattern of infant growth was associated with beneficial adult health outcomes. Larger infant size was associated with a reduced risk of ischemic heart disease, but also with an increased risk of type 1 diabetes. Very few or no studies associating infant size or growth with diseases such as cancer, mental illness, chronic obstructive disease, and type 2 diabetes were found. The authors identified a number of methodological limitations in the included trials. Furthermore, the authors stated that most of the evidence related to infant size, not to infant growth or actual size that is associated with the disease risk.
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