folic acid antagonist exposure [14]. Supplementary analyses
by tight matching with propensity scores restricting study
participants to first and second trimester exposure and to
specific categories of folic acid antagonists yielded similar
results. Folic acid antagonists include a broad spectrum of
drugs with a common mechanism of depleting maternal
folate. Findings from the effect of maternal exposure to folic
acid antagonists on the increased risk of PE add to the weight
of evidence that folic acid supplementation may decrease the
risk of PE