psychotic patient. Use with caution in trauma, acute inflection moderate-severe renal insufficiency, prolonged dietary insufficiencies , moderate-severe hypertension , polycythemia vera, vasculitis, open wound, active TB, history of PUD, anaphylactic disorder ,indwelling catheters, severe diabetes, thyroid disease, and mentruating and postpartum women. use with caution in protein C deficiency. use with caution in patients with heparin-induced thrombocytopenia and DVT . warfarin monotherapy is contraindicated in the initial treatment of active HIT