Supported by Novo Nordisk.
Disclosure forms provided by the authors are available with
the full text of this article at NEJM.org.
We thank all the patients, investigators, and trial-site staff
members who were involved in the conduct of the trial; Eirik
Quamme Bergan, M.D., and Lars Holm Damgaard, Ph.D. (both
from Novo Nordisk), for their review and suggestions for revis-
ing the manuscript; and Katrina de Saram, Ph.D., and Madeleine
Nowak, M.Sci. (both from AXON Communications), for medical
writing and editorial assistance.