The presence of goblet cell hyperplasia indicates that Aloe vera gel extract may have a protective effecton the intestinal mucosal barrier, which may contribute to its effectiveness in controlling coccidiosis inpoultry. Overall, the results of the histopathological examination support the use of Aloe vera gel extractas a natural supplement for controlling Eimeria infection in vaccinated and challenged chickens.Use of a live oocyst vaccine in broilers has become a widely accepted means of controlling coccidiosis. The commonly used live oocyst vaccines can beadministered to chicks at hatch using spray cabinets