Subsequently, the patients
often develop common age-related disorders including bilateral
ocular cataracts, type 2 diabetes mellitus, hypogonadism, osteoporosis,
atherosclerosis and cancers. Cancer is the most common
cause of death, and multiple cancers and sarcomas are not uncommon
in WS [7–11]. Persistent leg ulcers associated with soft tissue
calcification around Achilles tendons are highly characteristic to
WS [3]. Cells derived from WS patients show increased DNA deletions,
translocations, chromosomal breaks, and display replicative