Skin Structure and Function
Skin barrier functions as a first-line defense
against physical injuries, bacteria, viruses, allergens,
and also as protection against dehydration.
Therefore, its structural integrity and its
physiologic features are necessary for maintaining
its protective role. During terminal differentiation,
the epidermis, representing the
outermost layer of the skin, shows different features
reflecting several structural keratinocyte
modifications such as cornified cell envelope
e13
Skin Research and Technology 2013; 19: e13–e19
Printed in Singapore All rights reserved
doi: 10.1111/j.1600-0846.2011.00601.x
© 2011 John Wiley & Sons A/S
Skin Research and Technology
formation. The latter is constituted by loricrin,
involucrin, SPRR, enveloplakin, periplakin, and
it is assembled by transglutaminase I and transglutaminases
III (2).
Skin Structure and FunctionSkin barrier functions as a first-line defenseagainst physical injuries, bacteria, viruses, allergens,and also as protection against dehydration.Therefore, its structural integrity and itsphysiologic features are necessary for maintainingits protective role. During terminal differentiation,the epidermis, representing theoutermost layer of the skin, shows different featuresreflecting several structural keratinocytemodifications such as cornified cell envelopee13Skin Research and Technology 2013; 19: e13–e19Printed in Singapore All rights reserveddoi: 10.1111/j.1600-0846.2011.00601.x© 2011 John Wiley & Sons A/SSkin Research and Technologyformation. The latter is constituted by loricrin,involucrin, SPRR, enveloplakin, periplakin, andit is assembled by transglutaminase I and transglutaminasesIII (2).
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