High density lipoprotein (HDL) is known to possess atheroprotective
capacities including anti-oxidative properties [7,8]. Studies have
characterised HDL anti-oxidative properties by its ability to delay
LDL oxidation, typically monitored by the production of conjugated
diene. There is also a growing body of evidence highlighting the
defective anti-oxidative capacity of HDL in atherosclerosis. Decreased
protection of LDL against oxidation , and triglyceride and serum
amyloid A enrichment of HDL have all been associatedwith its impaired
anti-oxidative capacity. Earlier studies on HDL subpopulations
from normolipidemic individuals showed that small dense HDL3c exhibited
the greatest potency in inhibiting LDL oxidation. Analysis of the lipid
composition demonstrated that the small dense HDL3c was preferentially
enriched in sphingosine-1-phosphate, phosphatidylserine (PS),
and phosphatidic acid, and was depleted in sphingomyelin (SM)
.
High density lipoprotein (HDL) is known to possess atheroprotectivecapacities including anti-oxidative properties [7,8]. Studies havecharacterised HDL anti-oxidative properties by its ability to delayLDL oxidation, typically monitored by the production of conjugateddiene. There is also a growing body of evidence highlighting thedefective anti-oxidative capacity of HDL in atherosclerosis. Decreasedprotection of LDL against oxidation , and triglyceride and serumamyloid A enrichment of HDL have all been associatedwith its impairedanti-oxidative capacity. Earlier studies on HDL subpopulationsfrom normolipidemic individuals showed that small dense HDL3c exhibitedthe greatest potency in inhibiting LDL oxidation. Analysis of the lipidcomposition demonstrated that the small dense HDL3c was preferentiallyenriched in sphingosine-1-phosphate, phosphatidylserine (PS),and phosphatidic acid, and was depleted in sphingomyelin (SM).
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