Moreover, migration assays carried out confirmed that the major compound of CO, cinnamaldehyde, is progressively released from the active material in high concentrations. The results obtained suggest that the new procedure might be used to prepare active packaging multilayer materials for active packaging without a significantly increase in the cost of production. It can be pointed out that the chemical composition of the adhesive, used here as vehicle for antimicrobials in the multilayer system, is critical to get the reported antimicrobial activity. Besides, this technology might be used to control the release of the active agents by using inner laminate materials with appropriate thickness, chemical composition and structure.