In primary cultures of rat hepatocyte, PA (1–4mg/ml) increased %MTT and decreased the release of AST and/or ALT as compared to the effect of ethanol alone (Table 1).
In rat, single toxic dose of ethanol showed significantly increased levels of ALT and AST. Pretreatment with PA (25, 50 and 75 mg/kg) and SL (5 mg/kg) 24 h before ethanol decreased these levels toward normal. PA 75 mg/kg gave the best result sim- ilar to SL (Table 2). In ethanol 21 days treated rats, there were marked increase in levels of AST, ALT, H
In primary cultures of rat hepatocyte, PA (1–4mg/ml) increased %MTT and decreased the release of AST and/or ALT as compared to the effect of ethanol alone (Table 1).In rat, single toxic dose of ethanol showed significantly increased levels of ALT and AST. Pretreatment with PA (25, 50 and 75 mg/kg) and SL (5 mg/kg) 24 h before ethanol decreased these levels toward normal. PA 75 mg/kg gave the best result sim- ilar to SL (Table 2). In ethanol 21 days treated rats, there were marked increase in levels of AST, ALT, H
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