Practically, Jojoba meal is underutilized because it contains four anti-nutritional compounds represent 11-15% of the meal and collectively known as simmondsins (5-demethylsimmondsin, 4,5-didemethylsimmondsin, simmondsin, and simmondsin 2'-ferulate), that found unpalatable and have adverse effects on animals [27], which has been identified as the most responsible food intake inhibition and appetite suppression to rodents, rats, dogs, and chickens [17].