condensed in a reaction catalysed by thiolase to acetoacetyl-CoA, which is subsequently reduced to butyryl-CoA (analogous to boxidation of fatty acids). The CoA of butyryl-CoA is transferred via a CoA transferase to acetate, giving rise to acetyl-CoA, which is then fed into the acetate kinase reactiontoregenerateacetate,butmostimportantly,ATP. The overall reaction