Nutritional status may influence the bioavailability and hence toxic effects on the
gastrointestinal tract in several ways (George, 1984; Omaye, 1985; Aungst and Shen,
1986). In animal toxicological studies, there is an opportunity to obtain data on food and
fluid intake during the treatment period, and then to use these data (for the different
treatment groups and controls) as an indicator of gastrointestinal function. In many
studies of foods and food additives, much of the literature is focused on effects on
malignant and vascular disease states, with relatively few clinical chemistry
measurements.
Nutritional status may influence the bioavailability and hence toxic effects on thegastrointestinal tract in several ways (George, 1984; Omaye, 1985; Aungst and Shen,1986). In animal toxicological studies, there is an opportunity to obtain data on food andfluid intake during the treatment period, and then to use these data (for the differenttreatment groups and controls) as an indicator of gastrointestinal function. In manystudies of foods and food additives, much of the literature is focused on effects onmalignant and vascular disease states, with relatively few clinical chemistrymeasurements.
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