The activity of other species of Piper against M. tuberculosis has
been studied. Rukachaisirikul et al. (2002) isolated a novel piperine
dimer (chabamide) from stems of P. chaba, which showed an MIC of
12.5 mg/mL against M. tuberculosis H37Ra strain. In a review of
antitubercular natural products (Garcı´a et al., 2012), during the last
five years, only one species of Piper (P. sarmentosum) was found to
exhibit moderate inhibitory activity against M. tuberculosis H37Ra,
with MICs from 25 to 50 mg/mL