Since its identification more than 150 years ago, there has been an extensive characterisation of
glycogen
metabolism and its regulatory pathways in the two main glycogen storage organs of the body,
i.e.
liver and muscle. In recent years, glycogen metabolism has also been demonstrated to be upregulated
in
many tumour types, suggesting it is an important aspect of cancer cell pathophysiology. Here, we
provide
an overview of glycogen metabolism and its regulation, with a focus on its role in metabolic
reprogramming
of cancer cells. The various methods to detect glycogen in tumours in vivo are also
reviewed.
Finally,wediscussthetargetingofglycogenmetabolismasastrategyforcancertreatment.
Since its identification more than 150 years ago, there has been an extensive characterisation ofglycogen metabolism and its regulatory pathways in the two main glycogen storage organs of the body,i.e. liver and muscle. In recent years, glycogen metabolism has also been demonstrated to be upregulatedin many tumour types, suggesting it is an important aspect of cancer cell pathophysiology. Here, weprovide an overview of glycogen metabolism and its regulation, with a focus on its role in metabolicreprogramming of cancer cells. The various methods to detect glycogen in tumours in vivo are alsoreviewed.Finally,wediscussthetargetingofglycogenmetabolismasastrategyforcancertreatment.
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