The lack of Entrox-induced improvement in the absorption profile of ALA over 24 h period remains in
contrast to the previous report showing increased incorporation of Entrox-coated vs. non-coated EPA/DHA
formulation in red blood cell phospholipid membranes after 6wk administration to Crohn’s disease patients [10].
However, since in the Crohn’s disease study, changes in red blood cell phospholipid EPA and DHA levels were
measured only after chronic treatment, it can not be excluded that Entrox coating improves absorption of
fatty acids over longer periods of time. In support of this hypothesis, our results showed that 24 h after administration
of ALA supplements, plasma levels of ALA were significantly higher for Entrox-coated than for noncoated
formulation (Table 4 and Fig. 2).