Adoption of academic e-books and the movement away from print books remains a complex dynamic that is significantly influenced by one’s area of study or research. Comments by survey respondents who both use and prefer academic e-books over print books remind us that the transition is far from easy. Users need e-books that present usable interfaces, quality content, high resolution illustrations, access at the chapter and book level, and importantly, that are easily discoverable through both the library catalog and commercial search engines. As academic e-books become more broadly available and sophisticated in presentation and functionality, users’ expectations and acceptance of them will necessarily evolve. It is essential that those providing library and information services to the academic community continue to monitor and develop innovative services in support of the changing patterns of e-book use.