ANTIBIOTIC THERAPY
The authors recognize that the recommendations for the majority e of antibiotic regimens have been based on consensus, and that the optimal treatment for staphylococcal endocarditis and the empirical treatment are still under debate
Table
Changes Established in Antibiotic Therapy
Restrictions in aminoglycoside therapy:
Not recommended for native valve Staphylococcus aureus endocarditis
Administration in a single daily dose
Two weeks for enterococci and penicillin-resistant streptococci
Alternative regimen for Enterococcus endocarditis: ampicillin and ceftriaxone
New cutoffs to define penicillin-susceptible (MICso125 mglu, intermediate resistant (MIC 0.25-2 mg/L), and resistant (MIC 4 mg/L) streptococci
Nmurlinfls to define penicillin-susceptible (MIC s006 mgL), intermediate