Non-acute setting or maintenance: 25 to 100 mg PO daily
An aminoglycoside antibiotic derived from Streptomyces griseus that is used in the treatment of tuberculosis and sensitive Gram-negative infections.
Streptomycin is not absorbed from the gastrointestinal tract but, after intramuscular administration, it diffuses readily into the extracellular component of most body tissues and it attains bactericidal concentrations, particularly in tuberculous cavities. Little normally enters the cerebrospinal fluid, although penetration increases when the meninges are inflamed. The plasma half-life, which is normally 2-3 hours, is considerably extended in the newborn, in the elderly and in patients with severe renal impairment. It is excreted unchanged in the urine.