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Using nuclear power for desalination is a challenging option to reduce the cost of desalinated water in GCC countries. Although, nuclear reactors are used mainly for production of either heat or power but coupling MSF and RO with nuclear steam supply system can yield economical and technical advantages for producing desalted water. Many studies in Saudi Arabia indicated that the cost of effectiveness of nuclear desalination is a site dependent matter. The type of desalination process and the size and type of nuclear reactor have to be determined based on the specific sitedata [14].