A 33-year-old woman experienced severe right- or left-sided parietal–temporal throbbing headache accompanied by blurred vision, photophobia, vomiting, and anorexia at a frequency of 1–2 days per month since she was an adolescent. She was diagnosed with migraine without aura and received no prophylactic treatment. One month ago, she exhibited more severe, right-sided, parietal–temporal throbbing headaches characterized by a prolonged duration that increased in frequency to more than 15 days per month. She showed a poor medical response to sumatriptan and naproxen therapy. A few days after sumatriptan and naproxen therapy, she experienced the first MS episode of blurred vision over both the eyes and right facial numbness, which subsided quickly and spontaneously after 24 hours. Because the symptoms subsided quickly after 24 hours, the patient did not come to our outpatient department (OPD) at that time. No objective evidence of alteration of vision or facial sensation was observed. According to our detailed recordings of the patient’s history, she had never experienced these symptoms before.