Reviews the status of a number of ongoing or recently completed investigations of children vulnerable to schizophrenia as the 2nd half of a 2-part monograph. Various issues in risk research are then discussed. The increasing commitment to the study of the development of schizophrenia is considered to represent an appropriate stage in the evolution of psychiatric research. The main issue in risk research is held to be the demarcation of invulnerable, stress-resistant children born of a schizophrenic parent from those who will manifest maladaptation. It is suggested that the ultimate goal of risk research should be the generation of an intervention program to deter the occurrence of schizophrenia in children who have been identified as particularly vulnerable.