Ethnopharmacologicalrelevanceandbackground: “Dictamnus” wasapopularnameforagroupofmedicinal
herbaceousplantspeciesoftheRutaceaeandLamiaceae,whichsincethe4thcenturyhavebeenusedfor
gynaecologicalproblemsandotherillnessesBCEandstillappearinnumerousethnobotanicalrecords.
Aims: Thisresearchhasasfouroverarchingaims:
Determiningthehistoricalevolutionofmedicalpreparationslabelled “Dictamnus” andthedifferent
factorsaffectingthislong-standingherbaltradition.
Decipheringanddifferentiatingthosemedicinalusesof “Dictamnus” whichstrictlycorrespondto
Dictamnus (Rutaceae), fromthoseof Origanumdictamnus andotherLamiaceaespecies.
Quantitativelyassessingthedependencefromherbalbooks,andpharmaceuticaltradition,ofmodern
Dictamnus ethnobotanicalrecords.
DeterminingwhetherdifferencesbetweenWesternandEasternEuropeexistwithregardstothe
Dictamnusalbus usesinethnopharmacologyandethnomedicine.
Methods: An exhaustivereviewofherbals,classicalpharmacopoeias,ethnobotanicalandethnopharma-
cologicalliteraturewasconducted.Systematicanalysisofusesreportedwhichwerestandardizedac-
cordingtoInternationalClassificationofDiseases – 10andmultivariateanalysisusingfactorial,hierarchical
andneighbourjoiningmethodswasundertaken.
Resultsanddiscussion: Thepopularconcept “Dictamnus” includes Origanumdictamnus L., Ballotapseudo-
dictamnus (L.)Benth.and B. acetabulosa (L.)Benth.(Lamiaceae),aswellas Dictamnusalbus L. and D. his-
panicus WebbexWillk.(Rutaceae),with86differenttypesofuses.Between1000and1700CEnumerous
complexpreparationswith “Dictamnus” wereusedinthetreatmentof35differentpathologies.Onbio-
geographicalgroundsthewidespread D. albus is afarmorelikelyprototypical “Dictamnus” thantheCretan
endemic Origanumdictamnus. Howeverbothformintegralpartsofthe “Dictamnus” complex.
Evidenceexistsforasufficientlylongandcoherenttraditionfor D. albus and D. hispanicus, usetotreat
47differentcategoriesofdiseases.
Conclusions: Thisapproachisamodelforunderstandingtheculturalhistoryofplantsandtheirroleas
resourcesforhealthcare. “Dictamnus” showshowtransmissionoftraditionalknowledgeaboutmateria
medica,over26centuries,representsremarkablelevelsofdevelopmentandinnovation.Allthisleadusto
callattentionto D. albus and D. hispanicus whicharehighlypromisingaspotentialherbaldrugleads.The
nextstepsofresearchshouldbetosystematicallyanalysephytochemical,pharmacologicalandclinical
evidenceandtodevelopsafety,pharmacologyandtoxicologyprofilesofthetraditionalpreparations.
& 2015ElsevierIrelandLtd.Allrightsreserved.
Contents listsavailableat ScienceDirect
journal homepage: www.elsevier.com/locate/jep
Journal ofEthnopharmacology
http://dx.doi.org/10.1016/j.jep.2015.09.011
0378-8741/& 2015ElsevierIrelandLtd.Allrightsreserved.
Abbreviations: CSS, SupremeHealthCouncilofPoland(inthe19thcentury);ICD-10,WHOInternationalStatisticalClassification ofDiseasesandRelatedHealthProblems
10thRevision.Versionfor2010;NHM,NaturalHistoryMuseumofLondon
n Corresponding author.Fax: þ34 965903815.
E-mail addresses: vanessa.martinez@ua.es (V. Martínez-Francés), drivera@um.es (D. Rivera), m.heinrich@ucl.ac.uk (M. Heinrich), cobon@umh.es (C. Obón),
s.rios@ua.es (S. Ríos).
Journal ofEthnopharmacology175(2015)390–406
Ethnopharmacologicalrelevanceandbackground: "Dictamnus" wasapopularnameforagroupofmedicinalherbaceousplantspeciesoftheRutaceaeandLamiaceae, whichsincethe4thcenturyhavebeenusedforgynaecologicalproblemsandotherillnessesBCEandstillappearinnumerousethnobotanicalrecordsจุดมุ่งหมาย: Thisresearchhasasfouroverarchingaims:Determiningthehistoricalevolutionofmedicalpreparationslabelled "Dictamnus" andthedifferentfactorsaffectingthislong-standingherbaltraditionDecipheringanddifferentiatingthosemedicinalusesof "Dictamnus" whichstrictlycorrespondtoDictamnus วงศ์ (ส้ม), fromthoseof Origanumdictamnus andotherLamiaceaespeciesQuantitativelyassessingthedependencefromherbalbooks, andpharmaceuticaltradition, ofmodernDictamnus ethnobotanicalrecordsDeterminingwhetherdifferencesbetweenWesternandEasternEuropeexistwithregardstotheDictamnusalbus usesinethnopharmacologyandethnomedicineวิธีการ: เป็น exhaustivereviewofherbals, classicalpharmacopoeias, ethnobotanicalandethnopharma-cologicalliteraturewasconducted Systematicanalysisofusesreportedwhichwerestandardizedac-cordingtoInternationalClassificationofDiseases – 10andmultivariateanalysisusingfactorial ตามลำดับชั้นandneighbourjoiningmethodswasundertakenResultsanddiscussion: Thepopularconcept "Dictamnus" รวมถึง Origanumdictamnus L., Ballotapseudo-dictamnus (L.) Benth.and B. acetabulosa (L.) Benth (วงศ์กะเพรา), aswellas Dictamnusalbus L. และ d เขา -panicus WebbexWillk วงศ์ (ส้ม), with86differenttypesofuses Between1000and1700CEnumerouscomplexpreparationswith wereusedinthetreatmentof35differentpathologies "Dictamnus" Onbio-ไหลนา geographicalgroundsthewidespread D. เป็น afarmorelikelyprototypical "Dictamnus" thantheCretanOriganumdictamnus วี่ Howeverbothformintegralpartsofthe "Dictamnus" ซับซ้อนไหลนา Evidenceexistsforasufficientlylongandcoherenttraditionfor D. และ D. hispanicus, usetotreat47differentcategoriesofdiseasesบทสรุป: Thisapproachisamodelforunderstandingtheculturalhistoryofplantsandtheirroleasresourcesforhealthcare Showshowtransmissionoftraditionalknowledgeaboutmateria "Dictamnus"medica, over26centuries, representsremarkablelevelsofdevelopmentandinnovation Allthisleadustoไหลนา callattentionto D. และ D. hispanicus whicharehighlypromisingaspotentialherbaldrugleads ที่nextstepsofresearchshouldbetosystematicallyanalysephytochemical, pharmacologicalandclinicalevidenceandtodevelopsafety, pharmacologyandtoxicologyprofilesofthetraditionalpreparations& 2015ElsevierIrelandLtd.Allrightsreservedเนื้อหา listsavailableat ScienceDirectหน้าแรกของสมุดรายวัน: www.elsevier.com/locate/jepสมุด ofEthnopharmacologyhttp://dx.doi.org/10.1016/j.jep.2015.09.0110378-8741 / & 2015ElsevierIrelandLtd.Allrightsreservedตัวย่อ: CSS, SupremeHealthCouncilofPoland (inthe19thcentury) ICD-10, WHOInternationalStatisticalClassification ofDiseasesandRelatedHealthProblems10thRevision.Versionfor2010 NHM, NaturalHistoryMuseumofLondonผู้ Corresponding n โทรสาร: þ34 965903815ที่อยู่อีเมล: (V. Martínez-Francés) ใน vanessa.martinez@ua.es (ริเวอรา D.) ใน drivera@um.es (ไฮน์ริชเมตร) ใน m.heinrich@ucl.ac.uk (C. Obón), ใน cobon@umh.ess.rios@ua.es (S. Ríos).สมุด ofEthnopharmacology175 (2015) 390-406
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