Pre-clinical studies using bioactive compounds from botanicals appear to offer
some protection against cancer.
Research using single bioactives contributes greatly to our
understanding of their mechanism of action, but in vitro studies demand concentrations that are
higher than achievable in humans (µM). However, maintaining these bioactives in the presence
of other compounds originally derived from the food or extract of origin may synergistically
lower the bioactive dose so translatability becomes feasible.
The objective of this study was to
determine if bio-efficacy of phytonutrients can be enhanced when used in combination even at
doses that are ineffective for any compound when used in isolation.