Regardless of the answer, the current papers make a strong case for the toxic effects of excess carbohydrate
intake, placing fructose metabolism in the cross hairs. From an evolutionary perspective, enhanced fructose
conversion to fat may have been advantageous. For instance, because fruits ripen at the end of the growth season, starch conversion into fructose and, in turn, storage of the abundant fructose as fat rather than glycogen could have facilitated survival through the ensuing months of low food availability.