As the child reaches adolescence, the length of the face
increases to become long and slender. Other features developing
with maturing age include a prominent supra-orbital arch,
prominent, short philtrum, full lower lip and dental malocclusion
(open bite). A divergent strabismus is frequently observed
and metacarpals and metatarsals are commonly short, resulting
in small hands and feet. Premature greying of hair may also be
observed