Fewstudieshaveinvestigated theassociation between quality ofsleepandweaningfrommechanicalventilationinpatients. Thisstudythushelpsfillanimportantgapinrelatedresearch. Weidentifiedacloserelationshipbetweenqualityofsleepand disease severity among patients in RCCs and estimated the impactofthesefactorsonthesuccessofmechanicalventilation weaning. Initially, to reduce disease severity, clinical nurses mustprovideappropriatequalityhealthcaretopatients.Nurses mustbebettertrainedonhowtoproperlyexecutetheweaningprocess and on the key factors affecting quality of sleep and weaning outcomes. Hospital managers should provide the relevant education to nurses. Furthermore, there must be increased awareness among clinical nurses of the relationship betweenquality of sleep and weaning outcomes.In addition to the use of sleep medication, nurses may offer nonpharmacologicaltreatmentssuchaslisteningtorelaxingmusicand massage to improve sleep quality. Hypnotics are frequently prescribed to patients to treat sleeplessness and to relieve respiratory tract distress or improve oxygenation. The results of this study suggest that hypnotics do not negatively affect weaning outcomes and should continue to be administered. Inaddition,clinicalnursesandmedicalpersonnelmustevaluate the physical changes inpatientsandprovidesafeandeffective nonhypnoticmeasuresorhypnoticstohelppatientssleepand improve their sleep quality. However, identifying the key factors that affect the success of weaning from a mechanical ventilatorisusefultothemedicalteaminimprovingcareand management for patients undergoing the weaning process.