In in vitro and in vivo studies on human isolated
bronchus, and in normal or asthmatic subjects following
aerosol administration, respectively, LTC4 and LTD4 are
approximately 1,000 times more potent than histamine
in contracting human isolated bronchus [20–23]. Both
large and small airways of normal and asthmatic patients
are constricted by cysteinyl leukotrienes [22, 23]. Inhaled
LTC4 and LTD4 are l,000–5,000 times more potent
than histamine, with a long duration of action [22, 24]
In in vitro and in vivo studies on human isolatedbronchus, and in normal or asthmatic subjects followingaerosol administration, respectively, LTC4 and LTD4 areapproximately 1,000 times more potent than histaminein contracting human isolated bronchus [20–23]. Bothlarge and small airways of normal and asthmatic patientsare constricted by cysteinyl leukotrienes [22, 23]. InhaledLTC4 and LTD4 are l,000–5,000 times more potentthan histamine, with a long duration of action [22, 24]
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