Matrix solid phase dispersion (MSPD) has found particular
application as an analytical process for the preparation,
extraction and fractionation of solid, semi-solid and/or highly
viscous biological samples. Its simplicity and flexibility have
been cited as contributing to it being chosen over more classical
methods for these purposes. Indeed, MSPD is based on several
simple principles of chemistry and physics, involving forces
applied to the sample by mechanical blending to produce
complete sample disruption and the interactions of the sample
matrix with a solid support bonded-phase (SPE) or the surface
chemistry of other solid support materials.