To address this problem, researchers have explored
the possibility of stratifying patients with
colon cancer according to the gene-expression
profile of their tumor tissues, and they have
developed multigene-expression signatures that
can be used to identify high-risk colon cancers.
10-15 Although gene-expression signatures
hold promise, they are difficult to use in clinical
practice16 and are often not predictive of benefit
from adjuvant chemotherapy.17