∼fourfold increase in the IC50 (∼4.3 μg/mL). In comparison
with the free DOX (∼0.49 μg/mL for HeLa cells and ∼0.74
μg/mL for COS7 cells), there was an increase in the IC50 of the
DOX@MSN-GFLGR7RGDS/α-CD nanoparticles, but the
selectivity was significantly improved, which was extremely
important for clinical cancer chemotherapy.