The correction and prevention of traumatic coagulopathy (acute coagulopathy of trauma, ACoT) have become central goals of early resuscitative management of
hemorrhagic shock. As Figure 2 il lustrates, several interacting mechanisms contribute to the development of traumatic coagulopathy:
1) “Loss-dilution” phenomenon: bleeding and hemodilution secondary to fluid resuscitation cause a loss of coagulation factors and platelets.