Clinically, profound hypothermia is induced to minimize or prevent cerebral ischemic injury dur ing certain types of cardiac and cerebrovascular The beneficial effects of clinically in surgeries duced hypothermia classically have been attributed to a temperature-dependent reduction in metabo lism. 2,43 As a result, whole-body circulation can be arrested for prolonged periods, exceeding 30 minutes without incurring severe cerebral 39,4244 injury.