Asia House's headquarters at 63 New Cavendish Street, London is a Grade II* listed building, originally planned by Robert and James Adam on the Duke of Portland’s Marylebone Estate in the 1770s. By 1775, however, the Adams’ attention had turned to the creation of Portland Place, and neo-classical architect John Johnson took over the site, erecting the townhouse that has since been redeveloped as Asia House. The rooms retain many of their original features – including bookcases designed by Sir John Soane and plaster cornicing – while other parts of the building have been modernised to create café and gallery spaces.
In November 2010, Asia House expanded its mission to fully embrace the reemergent Silk Road region as a landbridge between Asia and Europe with the launch at the House of Lords of the Central Asia and South Caucasus Association (CASCA). The new association will expand and amplify Asia House's business and cultural programmes to include Central Asia (Kazakhstan, Uzbekistan, Turkmenistan, Kyrgyzstan and Tajikistan), the Southern Caucasus (Armenia, Azerbaijan and Georgia) as well as Mongolia, a region broadly defined in prior centuries as Inner Asia.