The absolute cancer incidence
In analyses restricted to participants who were current smokers at enrollment, long-term daily aspirin use was not associated with reduced risk of cancer among either men (RR = 1.08, 95% CI = 0.80 to 1.45) or women (RR = 1.13, 95% CI = 0.72 to 1.76), although statistical power was limited by the low prevalence of smoking, and these results should therefore be interpreted cautiously. In analyses by follow-up interval, the rate ratio for cancer associated with long-term daily aspirin use among men was 0.89 (95% CI = 0.75 to 1.06) during the 1992 – 1997 interval and 0.81 (95% CI = 0.71 to 0.92) during the 1997 – 2003 interval. The rate ratio for cancer associated with long-term daily aspirin use among women was 0.94 (95% CI = 0.70 to 1.26) during the 1992 – 1997 interval and 0.79 (95% CI = 0.64 to 0.99) during the 1997– 2003 interval.