Abstract
In this work, a new multi-residue methodology using liquid chromatography–time-of-flight mass spectrometry (LC–TOF-MS) for the
quantitative (routine) analysis of 15 pesticide residues has been developed. The analytical performance of the methodwas evaluated for different
types of fruit and vegetables: pepper, broccoli, tomato, orange, lemon, apple and melon. The accurate mass measurements were compared
in different matrices at significantly different concentration levels (from 0.01 to 0.5 mg/kg) obtaining accuracy errors lower than 2 ppm,
which is well within the accepted limits for elemental confirmation. Linearity of response over two orders of magnitude was demonstrated
(r > 0.99). Matrix effects resulting in suppression or enhancement of the response were frequently observed, most notably in broccoli and
citrus. Instrumental limits of detection (LOD) were between 0.0005 and 0.03 mg/kg depending on the commodity and pesticide studied, all
being within European Union regulations for food monitoring program. Finally, the methodology was applied to the analysis of two samples
from an inter-laboratory exercise. The high degree of confirmation for target pesticides by accurate mass measurements demonstrated the
applicability of the method in routine analysis. This study is a valuable indicator of the potential of LC–TOF-MS for quantitative multi-residue
analysis of pesticides in vegetables and fruits.
© 2005 Published by Elsevier B.V.
AbstractIn this work, a new multi-residue methodology using liquid chromatography–time-of-flight mass spectrometry (LC–TOF-MS) for thequantitative (routine) analysis of 15 pesticide residues has been developed. The analytical performance of the methodwas evaluated for differenttypes of fruit and vegetables: pepper, broccoli, tomato, orange, lemon, apple and melon. The accurate mass measurements were comparedin different matrices at significantly different concentration levels (from 0.01 to 0.5 mg/kg) obtaining accuracy errors lower than 2 ppm,which is well within the accepted limits for elemental confirmation. Linearity of response over two orders of magnitude was demonstrated(r > 0.99). Matrix effects resulting in suppression or enhancement of the response were frequently observed, most notably in broccoli andcitrus. Instrumental limits of detection (LOD) were between 0.0005 and 0.03 mg/kg depending on the commodity and pesticide studied, allbeing within European Union regulations for food monitoring program. Finally, the methodology was applied to the analysis of two samplesfrom an inter-laboratory exercise. The high degree of confirmation for target pesticides by accurate mass measurements demonstrated theapplicability of the method in routine analysis. This study is a valuable indicator of the potential of LC–TOF-MS for quantitative multi-residueanalysis of pesticides in vegetables and fruits.© เผยแพร่เมื่อปี 2005 โดย Elsevier b.v
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บทคัดย่อในงานนี้หลายใหม่- วิธีการตกค้างโดยใช้ของเหลว - เวลา- ของ- มวลสารบิน - TOF - MS) สำหรับปริมาณ( ผลการดำเนินงานวิเคราะห์ของ ประเมินที่แตกต่างกันสำหรับประเภทผักและผลไม้พริกไทยบรอกโคลีมะเขือเทศ Abstract
In this work, a new multi-residue methodology using liquid chromatography–time-of-flight mass spectrometry (LC–TOF-MS) for the
quantitative (routine) analysis of 15 pesticide residues has been developed. The analytical performance of the methodwas evaluated for different
types of fruit and vegetables: pepper, broccoli, tomato, orange, lemon, apple and melon. The accurate mass measurements were compared
in different matrices at significantly different concentration levels (from 0.01 to 0.5 mg/kg) obtaining accuracy errors lower than 2 ppm,
which is well within the accepted limits for elemental confirmation. Linearity of response over two orders of magnitude was demonstrated
(r > 0.99). Matrix effects resulting in suppression or enhancement of the response were frequently observed, most notably in broccoli and
citrus. Instrumental limits of detection (LOD) were between 0.0005 and 0.03 mg/kg depending on the commodity and pesticide studied, all
being within European Union regulations for food monitoring program. Finally, the methodology was applied to the analysis of two samples
from an inter-laboratory exercise. The high degree of confirmation for target pesticides by accurate mass measurements demonstrated the
applicability of the method in routine analysis. This study is a valuable indicator of the potential of LC–TOF-MS for quantitative multi-residue
analysis of pesticides in vegetables and fruits.
© 2005 Published by Elsevier B.V.
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