Emergent challenges in medical education support an implementation of trans-disciplinary case-based learning. We propose a
case-based blended learning framework, synergistically combining textbook, e-learning cases and a simulated patient course in
medical education. A novel server system architecture allows patient data to be automatically transferred from the Vienna
General Hospital to the Medical University of Vienna, and then imported into an e-learning template, in which online MCQ
questions can be generated. We present one example of a transferred, imported and completed anxiety disorder e-learning case,
currently implemented in the pre-clinical psychiatry course. This framework facilitates the creation of up to date teaching
content, while addressing difficulties in transforming declarative knowledge into procedural-knowledge and -skill, (background
knowledge into clinical reasoning) especially in domains which profit from a structured learning approach in creating a close link
in understanding between functional morphology and clinical presentation.