4. Discussion
Not only hyperglycemia but also instability of blood glucose
fluctuations induces oxidative stress, and has been shown to
have the potential to promote macrovascular disease [22–24].
Therefore, accurate determination of individual blood glucose
fluctuations is indispensable for deciding upon approaches to
diabetes treatment. Previous studies reported that blood
glucose fluctuation parameters such as SD and M-value
obtained by SMBG and/or CGM are useful for evaluation of
glycemic excursions [13,15,16].
HbA1c is the most commonly used evaluation method of
blood glucose control in clinical treatment. It has been
reported that although HbA1c merely indicates the mean
blood glucose level, it is insufficient for evaluation of
hypoglycemia or blood glucose fluctuations [15,25–29]. In
the present study, correlations were found between HbA1c
and mean blood glucose levels obtained by CGM and SMBG.
Sartore et al. showed that a positive correlation was found
between HbA1c and HBGI in patients with T1DM, and similar
results were found in the present study [27]. HbA1c is therefore
considered to be useful for evaluating mean blood glucose